Prostate-specific antigen

Prostate-specific antigen (PSA) is a protein present in humans. It is encoded by the gene KLK3, which is regulated by androgen receptors. It is present in high concentrations in both male and female ejaculate.

Response to antiandrogens
Bicalutamide inhibits PSA levels due to androgen receptor antagonism, while 5α-Reductase inhibitors (e.g. finasteride, dutasteride) inhibit PSA levels by decreasing DHT concentration.

Reference ranges
The following reference ranges are for serum concentrations. Serum PSA levels may be increased by prostatitis, benign prostatic hyperplasia (BPH), and recent ejaculation.