Selective estrogen receptor modulator

Selective estrogen receptor modulator (SERM) are a class of drugs that have tissue selective estrogen receptor agonism and antagonism. For example, raloxifene acts as an estrogen in bone but an antiestrogen in breast and uterine tissue.

Comparison
a Afimoxifene has only been delivered topically to the breast. However, since afimoxifene is the active metabolite of tamoxifen, it likely has the same effects as tamoxifen in bone and uterine tissue.