HRT contraindications

Contraindications are situations in which a procedure may be harmful of ineffective, here we're compiling a list of such things which may interact in a negative way with HRT.

Venous Thromboembolism
Deep vein thrombosis (DVT) was largely regarded as a risk heightened by hormone replacement therapy based on studies exploring the effects of estrogen and estrogen-progestin on post-menopausal women. This data has proven beneficial in suggesting transdermal HRT decreases the risk in contrast to oral method of administration and that age of an individual also increases DVT in conjunction with estrogen

Thanks to a recent study was prior used to prove the DVT risk, but it focused entirely on ethinyl estradiol in contrast to the more commonly prescribed 17b-estradiol.


 * nicotine use can increase risk of deep vein thrombosis which is already a significant risk with consuming exogenous estrogen, to the point some doctors will insist on the patient quitting prior to prescribing HRT. It is also an antagonist at estrogen receptor beta and has thus been implicated in causing detrimental effects in brains.
 * coffee in excessive quantities can accelerate estrogen metabolism by upregulating the enzyme responsible for metabolizing both caffiene and 17b-estradiol, and thus lead to depletion of administered estrogen faster than would otherwise occur.