Selective hormone receptor degrader

Selective hormone receptor degraders are a class of drugs that promote the degradation/breakdown of a particular nuclear receptor. They bind to a receptor and destabilize the protein, causing it to be degraded through the normal protein degradation process. For example, the selective estrogen receptor modulator fulvestrant promotes the breakdown of estrogen receptors.

The use of selective hormone receptor degraders in trans people has not been studied. However, they could presumably be used similar to how antiestrogens and antiandrogens are used today: to prevent feminization or masculinization due to estrogens and androgens, respectively. Additionally, SERM/SERD hybrids such as elacestrant may be useful in combination with an estrogen for people who desire tissue-specific feminization.

Selective estrogen receptor degraders (SERD)
Similar to GnRH agonists and antagonists, SERDs that are not tissue selective come with a risk of osteoporosis.