HRT contraindications

Contraindications are situations in which a procedure may be harmful of ineffective, here we're compiling a list of such things which may interact in a negative way with HRT.

Feminizing HRT contraindications

 * nicotine use can increase risk of deep vein thrombosis which is already a significant risk with consuming exogenous estrogen, to the point some doctors will insist on the patient quitting prior to prescribing HRT. It is also an antagonist at estrogen receptor beta and has thus been implicated in causing detrimental effects in brains.
 * coffee in excessive quantities can accelerate estrogen metabolism by upregulating the enzyme responsible for metabolizing both caffiene and 17b-estradiol, and thus lead to depletion of administered estrogen faster than would otherwise occur.