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Skeletal formula of enzalutamide
Drug class: Nonsteroidal antiandrogen
Brand names: Xtandi

Enzalutamide is a nonsteroidal antiandrogen, similar to bicalutamide. It has a higher binding affinity to the androgen receptor than bicalutamide.


Unlike bicalutamide, enzalutamide is associated with an increased risk of seizures. This may be due to off-target GABAA inhibition. See Wikipedia:Enzalutamide#Central adverse effects for more information.