Naturally occurring non-binary HRT

Highly-Experimental Research

PLEASE DON'T TRY THIS AT HOME! This is highly experimental and incredibly dangerous stuff.
Though if you are a professional looking for some new research idea, then by all means you're welcome to use our hypothesis in a study. ❤

This is not a Guide

We strive to provide non-biased, well cited, and accurate information, but this wiki is written by people who may or may not be professionals.
Therefore this is not medical advice, and any information you find here should be verified through professional sources before regarding it as fact. ❤

ERβ agonism

There is some evidence to suggest that certain phytoestrogens may act in a way analoguous to Selective Estrogen Receptor Modulators (SERMs). These phytoestrogens are reported to have a high affinity and agonism at ERβ, but a weak affinity and agonism at ERα.[1] The point being that ERβ has a negative effect on mammary cell proliferation [2] thus it may be plausible to use such phytoestrogens if AFAB, or in conjunction with feminizing HRT to minimize breast growth while increasing other feminine features.

Naturally occuring ERβ agonists

Isoflavones in particular are able to displace 17β-Estradiol at ER, among them the isoflavone genistein is known to directly agonize ERβ. This class of phytoestrogens are found predominantly in soy products.

  • Glycine max (Soy bean)

Many plants contain Apigenin which is known to preferentially bind to and activate ERβ [3]

  • Celery
  • Chamomile
  • Parsley
  • Celeriac
  • Damiana

Potential Risks

Extended treatment with some non-synthetic sources of hormone replacement therapy is highly experimental and very little is known about it's long term effects. In the case of phyto- or xeno- hormones some are so obscure that it could be difficult to test for their blood concentration levels and thus proper regulation of dosage is impaired. In addition, dosage regulation is further impaired unless a proper extraction of the active constituent(s) is made, as the amount of substance in a given organism can vary batch to batch.


  1. Selective Estrogen Receptor Modulators and Phytoestrogens |
  2. Estrogen Receptor Beta Is A Negative Regulator Of Mammary Cell Proliferation |
  3. Botanical modulation of menopausal symptoms: Mechanisms of action? |