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HRT and brain change

HRT may actually cause brain volume changes, of both the hypothalamus and whole brain volume size, to match cisgender levels.[1] It's not clear to me what to make of this.




  1. Changing your sex changes your brain: influences of testosterone and estrogen on adult human brain structure
  2. Biosynthesis, mode of action, and functional significance of neurosteroids in the Purkinje cell Kazuyoshi Tsutsui*, Kazuyoshi Ukena, Hirotaka Sakamoto, Shin-Ichiro Okuyama and Shogo Haraguchi Front. Endocrinol., 28 October 2011 |